Picomolar level profiling of the methylation status of the p53 tumor suppressor gene by a label-free electrochemical biosensor.
نویسندگان
چکیده
An efficient electrochemical approach is developed for ultrasensitive profiling of the methylation status of the p53 tumor suppressor gene based on a label-free biosensor in combination with bisulfite conversion.
منابع مشابه
Promoter hypermethylation of KLOTHO; an anti-senescence related gene in colorectal cancer patients of Kashmir valley
Hypermethylation of CpG islands located in the promoter regions of genes is a major event in the development of the majority of cancer types, due to the subsequent aberrant silencing of important tumor suppressor genes. KLOTHO; a novel gene associated primarily with suppressing senescence has been shown to contribute to tumorigenesis as a result of its impaired function. Recently the relevance ...
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عنوان ژورنال:
- Chemical communications
دوره 48 87 شماره
صفحات -
تاریخ انتشار 2012